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Two months after withdrawal of imatinib, he gradually developed tightness in the extremities with ‘peau d’orange’ appearing on both his forearms (Figure 1a).In addition, he developed rigidity with decreased range of joint motion.The CD3-positive T-cell counts of each DLI were 1.0 × 10 cells per kg. He developed mild chronic GVHD symptoms such as dry eye and oral mucosal involvement, which were manageable with supportive therapies.Imatinib was reduced to 600 and 400 mg daily, 9 and 12 months after transplantation, respectively, and discontinued 15 months after transplantation.
Go Fund Me receives over 0 million in donations per month. In June 2015, it was announced that Damphousse and Ballester had agreed to sell a majority stake in Go Fund Me to Accel Partners and Technology Crossover Ventures.PDGF and transforming growth factor-β are crucial in the development of fibrosis.Imatinib strongly inhibits PDGF and transforming growth factor-β signalling through the blockade of the PDGF receptor and c-abl, respectively.Although we determined the starting dose of imatinib as 400 mg, smaller doses may be sufficient. Go Fund Me is a crowdfunding platform that allows people to raise money for events ranging from life events such as celebrations and graduations to challenging circumstances like accidents and illnesses.The patient was diagnosed with fasciitis as a manifestation of chronic GVHD by Gd-enhancement of the fascia in magnetic resonance imaging images.Administration of prednisolone (PSL) was started; dry eye and oral mucosal involvement had not worsened until then.On post transplant day 81, RT-PCR for minor BCR-ABL was positive.We stopped Cs A and started imatinib 800 mg daily, followed by DLI for 2 consecutive months.Go Fund Me is unique to crowdfunding in that they are not an incentive-based crowdfunding website.Although it does allow projects that are meant to fund other projects for musicians, inventors, etc., the business model is set up to allow for donations to personal causes and life events such as medical bills.